[Magazines & News Articles][Journal Articles][Theses]

Shyamsunder Erramilli Professor Boston University Chairman, Assoc. Grad Studies CAS Physics 590 Commonwealth Ave Office: (617) 353-2600 Email: shyam http://physics.bu.edu/biophysics/

Biography

RESEARCH INTERESTS:

The Erramilli group works on developing high-resolution infrared microscopy for studying biological systems. Images with spatial and temporal information add to our understanding of these systems. Vibrational spectroscopy is an exquisitely sensitive tool for studying the many biomolecular systems that exhibit characteristic “fingerprint” absorption bands. Combining this sensitivity with microscopy allows the imaging of living systems without using stains or labels. But conventional infrared microscopy is limited to poor spatial resolution set by the diffraction limit associated with the longer wavelengths involved. Scanning near-field infrared microscopy is used to break the diffraction limit without sacrificing the spectral sensitivity. A variety of bright infrared sources are used – broadband synchrotron radiation, free electron lasers, ultra fast tunable infrared lasers, and quantum cascade lasers.

Using this system, the first ever high-resolution underwater infrared images of single living cells have been obtained. Images of single fibroblasts at wavelengths at which proteins, nucleic acids, and lipids absorb suggest that cell motion is associated with complex topological changes in the membrane.

Currently, time-resolved methods taking advantage of a tunable 100-fs laser are being used to do “vibrational lifetime” imaging in the mid-infrared region of the spectrum.

Vibrational dynamics of biomolecular systems are studied using femtosecond single color and two color pump-probe methods, and photon echo studies. Ultrafast studies on anesthetic molecules like nitrous oxide are aimed at solving the long-standing biological physics problem of how anesthetics act.

Magazines & News Articles

1.) M. K. Hong, A. K. Swan, and S. Erramilli, "Evanescent wave vibrational microscopy," Optics & Photonics News, 1 July 2004

Journal Articles

15.) E. R. Pinnick, S. Erramilli, and F. Wang, "The potential of mean force of nitrous oxide in a 1,2-dimyristotlphosphatidylcholine lipid bilayer," Chemical Physics Letters, Vol. 489, February 2010, pp. 96-98

14.) R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, "Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays," Proceedings of the National Academy of Science, Vol. 106, No. 46, November 2009, pp. 19227-19232

13.) A. A. Yanik, R. Adato, S. Erramilli, and H. Altug, "Hybridized nanocavities as single-polarized plasmonic antennas," Optics Express, Vol. 17, No. 23, November 2009, pp. 20900-20910

12.) S. Erramilli, "Solitons, from below," Journal of Biological Physics, Vol. 35, 2009, pp. 5-7

11.) J. Wenzler, T. Dunn, S. Erramilli, and P. Mohanty, "Nanoelectromechanical system-integrated detector with silicon nanomechanical resonator and silicon nanochannel field effect transistor," Journal of Applied Physics, 2009, pp. 094308

10.) J. P. Celli, B. S. Turner, N. H. Afdhal, S. E. Keates, I. C. Ghiran, C. P. Kelly, R. H. Ewoldt, G. H. McKinley, P. So, S. Erramilli, and R. Bansil, "Helicobacter pylori moves through mucus by reducing mucin viscoelasticity," Proceedings of the National Academy of Science, Vol. 106, No. 34, 2009, pp. 14321-14326

9.) A. A. Yanik, X. Wang, S. Erramilli, M. K. Hong, and H. Altug, "Extraordinary midinfrared transmission of rectangular coaxial nanoaperture arrays," Applied Physics Letters, Vol. 93, August 2008, pp. (081104)1-(081104)4

8.) Y. Chen, X. Wang, M. K. Hong, S. Erramilli, and P. Mohanty, "Surface-modified silicon nano-channel for urea sensing," Sensors and Actuators B, Vol. 133, 8 April 2008, pp. 593-598

7.) X. Wang, Y. Chen, K. A. Gibney, S. Erramilli, and P. Mohanty, "Silicon-based nanochemical glucose sensor," Applied Physics Letters, Vol. 92, 2008, pp. 013903

6.) J. P. Celli, B. S. Turner, N. H. Afdhal, R. H. Ewoldt, G. H. McKinley, R. Bansil, and S. Erramilli, "Rheology of gastric mucin exhibits a pH-dependent sol-gel transition," Biomacromolecules, Vol. 8, No. 5, May 2007, pp. 1580-1586

5.) J. J. Amsden, J. M. Kralj, L. R. Chieffo, X. Wang, S. Erramilli, E. N. Spudich, J. L. Spudich, L. D. Ziegler, and K. J. Rothschild, "Subpicosecond protein backbone changes detected during the green-absorbing proteorhodopsin primary photoreaction," Journal of Physical Chemistry B, Vol. 111, No. 40, 2007, pp. 11824-11831

4.) Y. Chen, X. Wang, M. K. Hong, S. Erramilli, P. Mohanty, and C. Rosenberg, "Nanoscale field effect transistor for biomolecular signal amplification," Applied Physics Letters, Vol. 91, 2007, pp. 243511

3.) Y. Chen, X. Wang, S. Erramilli, P. Mohanty, and A. Kalinowski, "Silicon-based nanoelectric field-effect pH sensor with local gate control," Applied Physics Letters, Vol. 89, 2006, pp. 223512

2.) J. Dorignac, A. Kalinowski, S. Erramilli, and P. Mohanty, "Dynamical Response of Nanomechanical Oscillators in Immiscible Viscous Fluid for In Vitro Biomolecular Recognition," Physical Review Letters, Vol. 96, 2006, pp. 186105

1.) J. P. Celli, B. Gregor, B. S. Turner, N. H. Afdhal, R. Bansil, and S. Erramilli, "Viscoelastic Properties and Dynamics of Porcine Gastric Mucin," Biomacromolecules, Vol. 6, 2005, pp. 1329-1333

Theses

1.) R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, "Radiative Engineering of NanoAntenna Arrays for Ultra-Sensitive Vibrational Spectroscopy of Proteins," Master Thesis, 2010