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Biography
RESEARCH INTERESTS:
*Development of biomaterials to
probe how structure, material properties and composition of the
cell-biomaterial interface affect fundamental cellular processes CURRENT FOCUS:
*Tissue engineering of small
diameter blood vessels for bypass and intravascular pharmacology (e.g.
stents) Cardiovascular disease is the leading
cause of death in the United States. While there have been tremendous
advances in the development of procedures to remove blockages in blood
vessels (e.g. angioplasty, bypass surgery, and stent implantation),
unfortunately a large number of these cases result in reformation of
the blockage - a process known as restenosis. A major cause of
restenosis is migration and growth of vascular smooth muscle cells
(VSMCs). A major effort in the laboratory aims to understand how
bioscaffold properties (e.g. structural, mechanical, and chemical)
affect VSMC migration and growth. By systematically varying these
bioscaffold properties, we hope to gain engineering design principles
for the fabrication of not only devices to treat restenosis but also
tissue-engineered blood vessels. Our laboratory fosters an
interdisciplinary environment that integrates materials science and
engineering, cell biology, microfabrication, and microscopy
.
Journal Articles16.) B. C. Isenberg, P. A. DiMilla, M. Walker, S. K. Kim, and J. Wong, "Vascular smooth muscle cell durotaxis depends on substrate stiffness gradient strength," Biophysical Journal, Vol. 97, September 2009, pp. 1313-1322 15.) E. Amstad, S. Zurcher, A. Mashaghi, J. Wong, M. Textor, and E. Reimhult, "Surface functionalization of single superparamagnetic iron oxide nanoparticles for targeted magnetic resonance imaging," Small, Vol. 5, No. 11, 2009, pp. 1334-1342 14.) C. Williams, J. Liao, E. M. Joyce, B. Wang, J. B. Leach, M. S. Sacks, and J. Wong, "Altered structural and mechanical properties in decellularized rabbid carotid arteries," Acta Biomaterialia, Vol. 5, No. 4, 2009, pp. 993-1005 13.) C. Williams, Y. Tsuda, B. C. Isenberg, M. Yamato, T. Shimizu, T. Okano, and J. Wong, "Aligned cell sheets grown on thermo-responsive substrates with microcontact printed protein patterns," Advanced Materials, Vol. 21, 2009, pp. 2161-2164 12.) J. Wong, and T. L. Kuhl, "Dynamics of Membrane Adhesion: The Role of Polyethylene Glycol Spacers, Ligand-Receptor Bond Strenght, and Rupture Pathway," Langmuir, Vol. 24, No. 4, 2008, pp. 1225-1231 11.) G. R. Houtchens, M. D. Foster, T. A. Desai, E. F. Morgan, and J. Wong, "Combined effects of microtopography and cyclic strain on vascular smooth muscle cell orientation," Journal of Biomechanics, Vol. 41, 2008, pp. 762-769 10.) B. C. Isenberg, Y. Tsuda, C. Williams, T. Shimizu, M. Yamato, T. Okano, and J. Wong, "A thermoresponsive, microtextured substrate for cell sheet engineering with defined structural organization," Biomaterials, Vol. 29, 2008, pp. 2565-2572 9.) S. Koster, H. M. Evans, J. Wong, and T. Pfohl, "An in situ study of collagen self-assembly processes," Biomacromolecules, Vol. 9, No. 1, 2008, pp. 199-207 8.) S. P. Arold, J. Wong, and B. Suki, "Design of a new stretching apparatus and the effects of cyclic strain and substratum on mouse lung epithelial-12 cells," Annals of Biomedical Engineering, Vol. 35, No. 7, July 2007, pp. 1156-1164 7.) J. B. Leach, X. Q. Brown, J. G. Jacot, P. A. DiMilla, and J. Wong, "Neurite outgrowth and branching of PC12 cells on very soft substrates sharply decreases below a threshold of substrate rigidity," Journal of Neural Engineering, Vol. 4, June 2007, pp. 26-34 6.) S. Koster, J. B. Leach, B. Struth, T. Pfohl, and J. Wong, "Visualization of flow-aligned type I collagen self-assembly in tunable pH gradients," Langmuir, Vol. 23, No. 2, 16 January 2007, pp. 357-359 5.) W. J. Duncanson, M. A. Figa, K. Hallock, S. Zalipsky, J. A. Hamilton, and J. Wong, "Targeted binding of PLA microparticles with lipid-PEG-tethered ligands," Biomaterials, Vol. 28, 2007, pp. 4991-4999 4.) S. Sarkar, G. Y. Lee, J. Wong, and T. A. Desai, "Development and characterization of a porous micro-patterned
scaffold for vascular tissue engineering applications," Biomaterials, Vol. 27, 2006, pp. 4775–4782 3.) X. Q. Brown, K. Ookawa, and J. Wong, "Evaluation of polydimethylsiloxane scaffolds with physiologically relevant elastic moduli: interplay of substrate mechanics and surface
chemistry effects on vascular smooth muscle cell response," Biomaterials, Vol. 26, 2005, pp. 3123–3129 2.) N. Zaari, P. Rajagopalan, S. K. Kim, A. Engler, and J. Wong, "Photopolymerization in Microfluidic Gradient Generators: Microscale Control of Substrate Compliance to Manipulate Cell Response," Advanced Materials, Vol. 16, No. 23-24, 17 December 2004, pp. 2133-2137 1.) K. A. Burridge, M. A. Figa, and J. Wong, "Patterning Adjacent Supported Lipid Bilayers of Desired
Composition To Investigate Receptor-Ligand Binding
under Shear Flow," Langmuir, No. 20, 2004, pp. 10252-10259 |
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