[Journal Articles]

Joyce Wong

Associate Professor
Boston University
44 Cummington Street
Boston, MA 02215
Office: (617) 353-2374
Email: jywong



*Development of biomaterials to probe how structure, material properties and composition of the cell-biomaterial interface affect fundamental cellular processes


*Tissue engineering of small diameter blood vessels for bypass and intravascular pharmacology (e.g. stents)
*Engineering biomimetic systems to study restenosis and breast cancer
*Development of targeted nano- and micro-particle contrast agents for multi-modal (magnetic resonance, ultrasound, and optical) detection of atherosclerotic and vulnerable plaque

Cardiovascular disease is the leading cause of death in the United States. While there have been tremendous advances in the development of procedures to remove blockages in blood vessels (e.g. angioplasty, bypass surgery, and stent implantation), unfortunately a large number of these cases result in reformation of the blockage - a process known as restenosis. A major cause of restenosis is migration and growth of vascular smooth muscle cells (VSMCs). A major effort in the laboratory aims to understand how bioscaffold properties (e.g. structural, mechanical, and chemical) affect VSMC migration and growth. By systematically varying these bioscaffold properties, we hope to gain engineering design principles for the fabrication of not only devices to treat restenosis but also tissue-engineered blood vessels. Our laboratory fosters an interdisciplinary environment that integrates materials science and engineering, cell biology, microfabrication, and microscopy


Journal Articles

20.) M. E. Kinahan, E. Filippidi, S. Koster, X. Hu, H. M. Evans, T. Pfohl, D. L. Kaplan, and J. Wong, "Tunable silk: using microfluidics to fabricate silk fibers with controllable properties," Biomacromolecules, Vol. 12, 26 March 2011, pp. 1504-1511

19.) C. Williams, X. Q. Brown, E. Bartolak-Suki, H. Ma, A. Chilkoti, and J. Wong, "The use of micropatterning to control smooth muscle myosin heavy chain expression and limit the response to transforming growth factor beta-1 in vascular smooth muscle cells," Biomaterials, Vol. 32, 2011, pp. 410-418

18.) M. Kim, B. C. Isenberg, J. Sutin, A. Meller, J. Wong, and C. M. Klapperich, "Programmed trapping of individual bacteria using micrometre-size sieves," Lab on a Chip, Vol. 11, 2011, pp. 1089-1095

17.) W. J. Duncanson, K. Oum, J. R. Eisenbrey, R. O. Cleveland, M. A. Wheatley, and J. Wong, "Targeted binding of PEG-lipid modified polymer ultrasound contrast agents with tiered surface architecture," Biotechnology and Bioengineering, Vol. 106, No. 3, 15 June 2010, pp. 501-506

16.) B. C. Isenberg, P. A. DiMilla, M. Walker, S. K. Kim, and J. Wong, "Vascular smooth muscle cell durotaxis depends on substrate stiffness gradient strength," Biophysical Journal, Vol. 97, September 2009, pp. 1313-1322

15.) E. Amstad, S. Zurcher, A. Mashaghi, J. Wong, M. Textor, and E. Reimhult, "Surface functionalization of single superparamagnetic iron oxide nanoparticles for targeted magnetic resonance imaging," Small, Vol. 5, No. 11, 2009, pp. 1334-1342

14.) C. Williams, J. Liao, E. M. Joyce, B. Wang, J. B. Leach, M. S. Sacks, and J. Wong, "Altered structural and mechanical properties in decellularized rabbid carotid arteries," Acta Biomaterialia, Vol. 5, No. 4, 2009, pp. 993-1005

13.) C. Williams, Y. Tsuda, B. C. Isenberg, M. Yamato, T. Shimizu, T. Okano, and J. Wong, "Aligned cell sheets grown on thermo-responsive substrates with microcontact printed protein patterns," Advanced Materials, Vol. 21, 2009, pp. 2161-2164

12.) J. Wong, and T. L. Kuhl, "Dynamics of Membrane Adhesion: The Role of Polyethylene Glycol Spacers, Ligand-Receptor Bond Strenght, and Rupture Pathway," Langmuir, Vol. 24, No. 4, 2008, pp. 1225-1231

11.) G. R. Houtchens, M. D. Foster, T. A. Desai, E. F. Morgan, and J. Wong, "Combined effects of microtopography and cyclic strain on vascular smooth muscle cell orientation," Journal of Biomechanics, Vol. 41, 2008, pp. 762-769

10.) B. C. Isenberg, Y. Tsuda, C. Williams, T. Shimizu, M. Yamato, T. Okano, and J. Wong, "A thermoresponsive, microtextured substrate for cell sheet engineering with defined structural organization," Biomaterials, Vol. 29, 2008, pp. 2565-2572

9.) S. Koster, H. M. Evans, J. Wong, and T. Pfohl, "An in situ study of collagen self-assembly processes," Biomacromolecules, Vol. 9, No. 1, 2008, pp. 199-207

8.) S. P. Arold, J. Wong, and B. Suki, "Design of a new stretching apparatus and the effects of cyclic strain and substratum on mouse lung epithelial-12 cells," Annals of Biomedical Engineering, Vol. 35, No. 7, July 2007, pp. 1156-1164

7.) J. B. Leach, X. Q. Brown, J. G. Jacot, P. A. DiMilla, and J. Wong, "Neurite outgrowth and branching of PC12 cells on very soft substrates sharply decreases below a threshold of substrate rigidity," Journal of Neural Engineering, Vol. 4, June 2007, pp. 26-34

6.) S. Koster, J. B. Leach, B. Struth, T. Pfohl, and J. Wong, "Visualization of flow-aligned type I collagen self-assembly in tunable pH gradients," Langmuir, Vol. 23, No. 2, 16 January 2007, pp. 357-359

5.) W. J. Duncanson, M. A. Figa, K. Hallock, S. Zalipsky, J. A. Hamilton, and J. Wong, "Targeted binding of PLA microparticles with lipid-PEG-tethered ligands," Biomaterials, Vol. 28, 2007, pp. 4991-4999

4.) S. Sarkar, G. Y. Lee, J. Wong, and T. A. Desai, "Development and characterization of a porous micro-patterned scaffold for vascular tissue engineering applications," Biomaterials, Vol. 27, 2006, pp. 47754782

3.) X. Q. Brown, K. Ookawa, and J. Wong, "Evaluation of polydimethylsiloxane scaffolds with physiologically relevant elastic moduli: interplay of substrate mechanics and surface chemistry effects on vascular smooth muscle cell response," Biomaterials, Vol. 26, 2005, pp. 31233129

2.) N. Zaari, P. Rajagopalan, S. K. Kim, A. Engler, and J. Wong, "Photopolymerization in Microfluidic Gradient Generators: Microscale Control of Substrate Compliance to Manipulate Cell Response," Advanced Materials, Vol. 16, No. 23-24, 17 December 2004, pp. 2133-2137

1.) K. A. Burridge, M. A. Figa, and J. Wong, "Patterning Adjacent Supported Lipid Bilayers of Desired Composition To Investigate Receptor-Ligand Binding under Shear Flow," Langmuir, No. 20, 2004, pp. 10252-10259

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