[Journal Articles]

Jerome Mertz

Boston University
44 Cummington Street
Boston, MA 02215
Office: (617) 358-0746
Email: jmertz



*HiLo microscopy
*Fluorescence Endoscopy
*Differential Aberration Imaging
*Nonlinear Microscopy
*Dynamic Speckle Illumination Microscopy
*Autoconfocal Microscopy
*Graded Field Microscopy

We are a research group (founded in 2003) in the Department of Biomedical Engineering that focuses on developing new microscope technologies for imaging biological tissue. Biomedical Engineering is an unusual field, in that it is defined by its applications rather than its areas of knowledge.  BME researchers are physicists, biologists, chemists, electrical engineers, mechanical engineers, and mathematicians who all strive to contribute to biology and medicine. Nowhere is multidisciplinary integration more evident than in the Biomicroscopy Lab.  Building a microscope requires knowledge of physics, electronics, and mechanical design.  We must also be familiar with biology and chemistry to understand and prepare the specimens we examine.  Our students arrive with diverse scientific backgrounds, and gain a piece of every part of the BME palette during their studies.

Journal Articles

16.) B. B. Goldberg, A. Yurt, Y. Lu, E. Ramsay, F. H. Koklu, J. Mertz, T. G. Bifano, and M. S. Ünlü, "Chromatic and spherical aberration correction for silicon aplanatic solid immersion lens for fault isolation and photon emission microscopy of integrated circuits," Microelectronics Reliability, Vol. 51, September/October 2011, pp. 1637-1639

15.) D. Lim, T. Ford, K. K. Chu, and J. Mertz, "Optically sectioned in vivo imaging with speckle illumination HiLo microscopy," Journal of Biomedical Optics, Vol. 16, No. 1, 31 January 2011

14.) J. Mertz, and J. Kim, "Scanning light-sheet microscopy in the whole mouse brain with HiLo background rejection," Journal of Biomedical Optics, Vol. 15, No. 1, January/February 2010

13.) S. Santos, K. K. Chu, D. Lim, N. Bozinovic, T. Ford, C. Hourtoule, A. C. Bartoo, S. K. Singh, and J. Mertz, "Optically sectioned fluorescence endomicroscopy with hybrid-illumination imaging through a flexible fiber bundle," Journal of Biomedical Optics, Vol. 14, No. 3, May/June 2009, pp. 030502

12.) D. Lim, K. K. Chu, and J. Mertz, "Wide-field fluorescence sectioning with hybrid speckle and uniform-illumination microscopy," Optics Letters, Vol. 33, No. 16, August 2008, pp. 1819-1821

11.) D. Lim, K. K. Chu, and J. Mertz, "Autoconfocal microscopy with a cw laser and thermionic detection," Optics Letters, Vol. 33, No. 12, June 2008, pp. 1345-1347

10.) N. Bozinovic, C. Ventalon, T. Ford, and J. Mertz, "Fluorescence endomicroscopy with structured illumination," Optics Express, Vol. 16, No. 11, May 2008, pp. 8016-8025

9.) A. Leray, K. Lillis, and J. Mertz, "Enhanced background rejection in thick tissue with differential-aberration two-photon microscopy," Biophysical Journal, Vol. 94, No. 4, February 2008

8.) G. M. Price, K. K. Chu, J. G. Truslow, M. D. Tang-Schomer, A. P. Golden, J. Mertz, and J. Tien, "Bonding of macromolecular hydrogels using perturbants," Journal of the American Chemical Society, Vol. 130, No. 21, 2008, pp. 6664-6665

7.) K. Lillis, A. Eng, J. A. White, and J. Mertz, "Two-photon imagine of spatially extended neuronal network dynamics with high temporal resolution," Journal of Neuroscience Methods, Vol. 172, 2008, pp. 178-184

6.) K. K. Chu, D. Lim, and J. Mertz, "Enhanced weak-signal sensitivity in two-photon microscopy by adaptive illumination," Optics Letters, Vol. 32, No. 19, October 2007, pp. 2846-2848

5.) C. Ventalon, R. Heintzmann, and J. Mertz, "Dynamic speckle illumination microscopy with wavelet prefiltering," Optics Letters, Vol. 32, No. 11, 1 June 2007, pp. 1417-1419

4.) K. K. Chu, R. Yi, and J. Mertz, "Graded-field autoconfocal microscopy," Optics Express, Vol. 15, No. 5, 5 March 2007, pp. 2476-2489

3.) T. Pons, and J. Mertz, "Membrane potential detection with second-harmonic generation and two-photon excited fluorescence: A theoretical comparison," Optics Communications, Vol. 258, 2006, pp. 203-209

2.) T. Pons, and J. Mertz, "Autoconfocal microscopy with nonlinear transmitted light detection," Journal of the Optical Society of America, Vol. 21, No. 8, August 2004

1.) J. Mertz, "Nonlinear microscopy: new techniques and applications," Current Opinion in Neurobiology, Vol. 14, 2004, pp. 610-616

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