[Journal Articles]

Irving Bigio

Boston University
44 Cummington Street
Boston, MA 02215
Office: (617) 358-1987
Fax: (617) 358-0389
Email: bigio



*Medical applications of optics, lasers and spectroscopy
* Biomedical Optics and Biophotonics
* Biomolecular dynamics
* Applied spectroscopy, especially to biomedical problems
* Nonlinear optics, quantum electronics and laser physics


* Advanced spectroscopic technologies for tissue diagnosis
* Noninvasive measurement of drug concentrations in tissue
* Interstitial laser thermotherapy and photodynamic therapy
* Computational methods for modeling optical transport in tissue
* Multi-capability endoscopic and laparoscopic instruments

The core theme of biomedical optics/photonics is minimally invasive optical diagnostics and therapeutics. The current national trend in health care is a growing emphasis on preventive medicine, early diagnosis, reduced invasiveness of procedures, outpatient procedures - in short, an overall reduction in the cost of providing health care. Minimally invasive techniques address such aims in addition to providing significant patient benefits. Current developments in optical technologies are rapidly increasing the technical options available. Moreover, the ongoing growth in use of endoscopes and laparoscopes in medicine makes this theme very timely.

Journal Articles

12.) K. Calabro, A. L. Curtis, J. Galarneau, T. Krucker, and I. Bigio, "Gender variations in the optical properties of skin in murine animal models," Journal of Biomedical Optics, Vol. 16, No. 1, 27 January 2011

11.) E. Rodriquez-Diaz, I. Bigio, and S. K. Singh, "Integrated optical tools from minimally invasive diagnosis and treatment at gastrointestinal endoscopy," Robotics and Computer-Integrated Manufacturing, Vol. 27, 2011, pp. 249-256

10.) H. Suh, O. A'Amar, E. Rodriquez-Diaz, S. Lee, I. Bigio, and J. E. Rosen, "Elastic light-scattering spectroscopy for discrimination of benign from malignant disease in thyroid nodules," Annals of Surgical Oncology, Vol. 18, 2011, pp. 1300-1305

9.) C. S. Mulvey, C. A. Sherwood, and I. Bigio, "Wavelength-dependent backscattering measurements for quantitative real-time monitoring of apoptosis in living cells," Journal of Biomedical Optics, Vol. 14, No. 6, November/December 2009

8.) Y. Zhu, T. Fearn, G. Mackenzie, B. Clark, J. M. Dunn, I. Bigio, S. G. Bown, and L. B. Lovat, "Elastic scattering spectroscopy for detection of cancer risk in Barrett's esophagus: experimental and clinical validation of error removal by orthogonal subtraction for increasing accruacy," Journal of Biomedical Optics, Vol. 14, No. 4, July/August 2009, pp. 04022

7.) R. Georgescu, D. Khismatullin, R. G. Holt, J. Castagner, O. A'Amar, and I. Bigio, "Design of a system to measure light scattering from individual cells excited by an acoustic wave," Optics Express, Vol. 16, No. 6, March 2008, pp. 3496-3503

6.) R. Reif, M. S. Amorosino, K. Calabro, O. A'Amar, S. K. Singh, and I. Bigio, "Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures," Journal of Biomedical Optics, Vol. 13, No. 1, January/February 2008, pp. 010502

5.) I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. D. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, and L. T. Perelman, "Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels," Proceedings of the National Academy of Science, Vol. 104, No. 44, October 2007, pp. 1725517260

4.) R. Reif, M. Wang, S. Loshi, O. A'Amar, and I. Bigio, "Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue," Journal of Biomedical Optics, Vol. 12, No. 3, May/June 2007, pp. 034036

3.) H. Fang, L. Qiu, E. Vitkin, M. M. Zaman, C. Andersson, S. Salahuddin, L. M. Kimerer, P. B. Cipolloni, M. D. Modell, B. S. Turner, S. E. Keates, I. Bigio, I. Itzkan, S. D. Freedman, R. Bansil, E. B. Hanlon, and L. T. Perelman, "Confocal light absorption and scattering spectroscopic microscopy," Applied Optics, Vol. 46, No. 10, 1 April 2007, pp. 1760-1769

2.) J. Castagner, and I. Bigio, "Particle sizing with a fast polar nephelometer," Applied Optics, Vol. 46, No. 4, 1 February 2007, pp. 527-532

1.) C. S. Mulvey, A. L. Curtis, S. K. Singh, and I. Bigio, "Elastic scattering spectroscopy as a diagnostic tool for apoptosis in cell cultures," IEEE Journal of Selected Topics in Quantum Electronics, Vol. 13, No. 6, 2007, pp. 1663-1670

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