[Journal Articles]

Catherine M. Klapperich Assistant Professor Boston University Assistant Professor 15 Saint Mary's Street Boston, MA 02215 Office: (617) 358-0253 Email: catherin http://www.klapperichlab.org/

Biography

RESEARCH INTERESTS:

CURRENT FOCUS:

The Biomedical Microdevices and Microenvironments Laboratory (BMML) is focused on the design and engineering of manufacturable, disposable microfluidic systems for low-cost point-of-care molecular diagnostics.We are currently working on devices for the detection of infectious diarrhea, influenza and MRSA.

We are also studying interactions between cells and synthetic microenvironments. Specifically, we are interested in building culture systems in vitro that mechanically mimic the physiological environment. These synthetic microenvironments are intended for use in diagnostics, high throughput drug screening, and to enable previously impossible basic science studies. Currently we have projects aimed at recapitulating the microenvironments of the breast, cochlea and neural tissue.

Dr. Catherine Klapperich joined the faculty of the Boston University College of Engineering in 2003. She is the director of the Biomedical Microdevices and Microenvironments Laboratory in the Departments of Biomedical and Manufacturing Engineering. She is also a member of the Center for Nanoscience and Nanotechnology at BU. Before coming to Boston, Dr. Klapperich was a Visiting Postdoctoral Fellow at Lawrence Berkeley Laboratory in the lab of Dr. Carolyn Bertozzi, and was a Senior Research Scientist at Aclara Biosciences in Mountain View, CA. She earned her Ph.D. in Mechanical Engineering in 2000 from the University of California, Berkeley; her M.S. in Engineering from Harvard University and her B.S. in Materials Science and Engineering at Northwestern.

Journal Articles

10.) J. D. Kaufman, and C. M. Klapperich, "Surface detection errors cause overestimation of the modulus in nanoindentation on soft materials," Journal of the Mechanical Behavior of Biomedical Materials, Vol. 2, 2009, pp. 312-317

9.) M. D. Kulinski, M. Mahalanabis, S. Gillers, J. Y. Zhang, S. K. Singh, and C. M. Klapperich, "Sample preparation module for bacterial lysis and isolation of DNA from human urine," Biomedical Microdevices, Vol. 11, 2009, pp. 671-678

8.) C. M. Klapperich, "Microfluidic diagnostics: time for industry standards," Expert Review of Medical Devices, Vol. 6, No. 3, 2009, pp. 211-213

7.) A. Bhattacharyya, and C. M. Klapperich, "Microfluidics-based extraction of viral RNA from infected mammalian cells for disposable molecular diagnostics," Sensors and Actuators B, Vol. 129, 2008, pp. 693-698

6.) J. D. Kaufman, G. J. Miller, E. F. Morgan, and C. M. Klapperich, "Time-dependent mechanical characterization of poly(2-hydroxyethyl methacrylate) hydrogels using nanoindentation and unconfined compression," Journal of Materials Research, Vol. 23, No. 5, 2008, pp. 1472-1481

5.) J. D. Kaufman, J. Song, and C. M. Klapperich, "Nanomechanical Analysis of Bone Tissue Engineering Scaffolds," Journal of Biomedical Materials Research A, Vol. 81A, No. 3, 1 June 2007, pp. 611-623

4.) A. Bhattacharyya, and C. M. Klapperich, "Design and testing of a disposable microfluidic chemiluminescent immunoassay for disease biomarkers in human serum samples," Biomedical Microdevices, 2007

3.) A. Bhattacharyya, and C. M. Klapperich, "Thermoplastic Microfluidic Device for On-Chip Purification of Nucleic Acids for Disposable Diagnostics," Analytical Chemistry, Vol. 78, No. 3, 1 February 2006, pp. 788-792

2.) J. Jaworski, and C. M. Klapperich, "Fibroblast remodeling activity at two- and three-dimensional collagen–glycosaminoglycan interfaces," Biomaterials, Vol. 27, 2006, pp. 4212–4220

1.) C. M. Klapperich, and C. R. Bertozzi, "Global gene expression of cells attached to a tissue engineering scaffold," Biomaterials, Vol. 25, 2004, pp. 5631–5641