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[Journal Articles]

Catherine M. Klapperich

Assistant Professor
Boston University
Assistant Professor
15 Saint Mary's Street
Boston, MA 02215
Office: (617) 358-0253
Email: catherin
http://www.bu.edu/klapperich

Biography

RESEARCH INTERESTS:

*Interactions between cells and synthetic microenvironments
*Building culture systems in vitro that mechanically mimic the physiological environment
*Design and engineering of manufacturable, disposable microfluidic systems for low-cost point-of-care molecular diagnostics

CURRENT FOCUS:

*Rapid Diagnostic for Influenza A
*SNAP: System for Nucleic Acid Purification
*Isolating Bacterial DNA from Blood
*Isolating Bacterial DNA from Urine and Stool


The Biomedical Microdevices and Microenvironments Laboratory (BMML) is focused on the design and engineering of manufacturable, disposable microfluidic systems for low-cost point-of-care molecular diagnostics.We are currently working on devices for the detection of infectious diarrhea, influenza and MRSA.

We are also studying interactions between cells and synthetic microenvironments. Specifically, we are interested in building culture systems in vitro that mechanically mimic the physiological environment. These synthetic microenvironments are intended for use in diagnostics, high throughput drug screening, and to enable previously impossible basic science studies. Currently we have projects aimed at recapitulating the microenvironments of the breast, cochlea and neural tissue.

Dr. Catherine Klapperich joined the faculty of the Boston University College of Engineering in 2003. She is the director of the Biomedical Microdevices and Microenvironments Laboratory in the Departments of Biomedical and Manufacturing Engineering. She is also a member of the Center for Nanoscience and Nanotechnology at BU. Before coming to Boston, Dr. Klapperich was a Visiting Postdoctoral Fellow at Lawrence Berkeley Laboratory in the lab of Dr. Carolyn Bertozzi, and was a Senior Research Scientist at Aclara Biosciences in Mountain View, CA. She earned her Ph.D. in Mechanical Engineering in 2000 from the University of California, Berkeley; her M.S. in Engineering from Harvard University and her B.S. in Materials Science and Engineering at Northwestern.

Journal Articles

17.) M. Kim, B. C. Isenberg, J. Sutin, A. Meller, J. Wong, and C. M. Klapperich, "Programmed trapping of individual bacteria using micrometre-size sieves," Lab on a Chip, Vol. 11, 2011, pp. 1089-1095

16.) J. Do, J. Y. Zhang, and C. M. Klapperich, "Maskless writing of microfluidics: rapid prototyping of 3D microfluidics using scratch on a polymer substrate," Robotics and Computer-Integrated Manufacturing, Vol. 27, 2011, pp. 245-248

15.) A. Chatterjee, P. Mirer, E. Z. Santamaria, C. M. Klapperich, A. Sharon, and A. Sauer-Budge, "RNA isolation from mammalian cells using porous polymer monoliths: an approach for high-throughput automation," Analytical Chemistry, Vol. 82, No. 11, 1 June 2010, pp. 4344-4356

14.) M. Mahalanabis, J. Do, H. Al-Muayad, J. Y. Zhang, and C. M. Klapperich, "An integrated disposable device for DNA extraction and helicase dependent amplification," Biomedical Microdevices, Vol. 12, 12 January 2010, pp. 353-359

13.) C. M. Klapperich, C. L. Noack, J. D. Kaufman, L. Zhu, L. Bonnaillie, and R. P. Wool, "A novel biocompatible adhesive incorporating plant-derived monomers," Journal of Biomedical Materials Research A, Vol. 91, No. 2, November 2009, pp. 378-384

12.) A. Sauer-Budge, P. Mirer, A. Chatterjee, C. M. Klapperich, D. Chargin, and A. Sharon, "Low cost and manufacturable complete microTAS for detecting bacteria," Lab on a Chip, Vol. 9, June 2009, pp. 2803-2810

11.) M. Mahalanabis, H. Al-Muayad, M. D. Kulinski, D. Altman, and C. M. Klapperich, "Cell lysis and DNA extraction of gram-positive and gram-negative bacteria from whole blood in a disposable microfluidic chip," Lab on a Chip, Vol. 9, June 2009, pp. 2811-2817

10.) J. D. Kaufman, and C. M. Klapperich, "Surface detection errors cause overestimation of the modulus in nanoindentation on soft materials," Journal of the Mechanical Behavior of Biomedical Materials, Vol. 2, 2009, pp. 312-317

9.) M. D. Kulinski, M. Mahalanabis, S. Gillers, J. Y. Zhang, S. K. Singh, and C. M. Klapperich, "Sample preparation module for bacterial lysis and isolation of DNA from human urine," Biomedical Microdevices, Vol. 11, 2009, pp. 671-678

8.) C. M. Klapperich, "Microfluidic diagnostics: time for industry standards," Expert Review of Medical Devices, Vol. 6, No. 3, 2009, pp. 211-213

7.) A. Bhattacharyya, and C. M. Klapperich, "Microfluidics-based extraction of viral RNA from infected mammalian cells for disposable molecular diagnostics," Sensors and Actuators B, Vol. 129, 2008, pp. 693-698

6.) J. D. Kaufman, G. J. Miller, E. F. Morgan, and C. M. Klapperich, "Time-dependent mechanical characterization of poly(2-hydroxyethyl methacrylate) hydrogels using nanoindentation and unconfined compression," Journal of Materials Research, Vol. 23, No. 5, 2008, pp. 1472-1481

5.) J. D. Kaufman, J. Song, and C. M. Klapperich, "Nanomechanical Analysis of Bone Tissue Engineering Scaffolds," Journal of Biomedical Materials Research A, Vol. 81A, No. 3, 1 June 2007, pp. 611-623

4.) A. Bhattacharyya, and C. M. Klapperich, "Design and testing of a disposable microfluidic chemiluminescent immunoassay for disease biomarkers in human serum samples," Biomedical Microdevices, 2007

3.) A. Bhattacharyya, and C. M. Klapperich, "Thermoplastic Microfluidic Device for On-Chip Purification of Nucleic Acids for Disposable Diagnostics," Analytical Chemistry, Vol. 78, No. 3, 1 February 2006, pp. 788-792

2.) J. Jaworski, and C. M. Klapperich, "Fibroblast remodeling activity at two- and three-dimensional collagen–glycosaminoglycan interfaces," Biomaterials, Vol. 27, 2006, pp. 4212–4220

1.) C. M. Klapperich, and C. R. Bertozzi, "Global gene expression of cells attached to a tissue engineering scaffold," Biomaterials, Vol. 25, 2004, pp. 5631–5641

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