[Journal Articles]

Amit Meller

Associate Professor
Boston University
Associate Professor
Office: (617) 358-4338
Email: ameller



*Employing nanopore force spectroscopy to study RNA unfolding and re-folding kinetics
*DNA switches and transcription initiation kinetics
*RNA helicases activity
*Mapping of transcription factors interactions with DNA
*Ultra fast DNA sequencing
*Development of novel optical methods for single molecule detection in biomedical applications

Dr. Meller's research is directed toward the development of novel experimental techniques for the study of biomolecular interactions and dynamics, at the single molecule or at the single complex level.

Journal Articles

27.) M. Kim, B. C. Isenberg, J. Sutin, A. Meller, J. Wong, and C. M. Klapperich, "Programmed trapping of individual bacteria using micrometre-size sieves," Lab on a Chip, Vol. 11, 2011, pp. 1089-1095

26.) M. Livingstone, E. Atas, A. Meller, and N. Sonenberg, "Mechanisms governing the control of mRNA translation," Physical Biology, Vol. 7, No. 2, 12 May 2010

25.) B. McNally, A. Singer, Z. Yu, Y. Sun, Z. Weng, and A. Meller, "Optical recognition of converted DNA nucleotides for single-molecule DNA sequencing using nanopore arrays," Nano Letters, Vol. 10, 11 May 2010, pp. 2237-2244

24.) N. Di Fiori, and A. Meller, "The effect of dye-dye interactions on the spatial resolution of single-molecule FRET measurements in nucleic acids," Biophysical Journal, Vol. 98, No. 10, May 2010, pp. 2265-2272

23.) V. Viasnoff, U. Bockelmann, A. Meller, H. Isambert, L. Laufer, and Y. Tsori, "Localized Joule heating produced by ion current focusing through micron-sized holes," Applied Physics Letters, Vol. 96, No. 16, 19 April 2010

22.) J. Lin, A. Kolomeisky, and A. Meller, "Helix-coil kinetics of individual polyadenylic acid molecules in a protein channel," Physical Review Letters, Vol. 104, No. 15, 16 April 2010

21.) M. Wanunu, W. Morrison, Y. Rabin, A. Y. Grosberg, and A. Meller, "Electrostatic focusing of unlabelled DNA into nanoscale pores using a salt gradient," Nature Nanotechnology, Vol. 5, February 2010, pp. 160-165

20.) A. Singer, M. Wanunu, W. Morrison, H. Kuhn, M. Frank-Kamenetskii, and A. Meller, "Nanopore based sequence specific detection of duplex DNA for genomic profiling," Nano Letters, Vol. 10, 20 January 2010, pp. 738-742

19.) G. V. Soni, A. Singer, Z. Yu, Y. Sun, B. McNally, and A. Meller, "Synchronous optical and electrical; detection of biomolecules traversing through solid-state nanopores," Review of Scientific Instruments, Vol. 81, No. 1, 19 January 2010

18.) M. Valencia-Burton, A. Shah, J. Sutin, A. Borogovac, R. M. McCullough, C. R. Cantor, A. Meller, and N. E. Broude, "Spatiotemporal patterns and transcription kinetics of induced RNA in single bacterial cells," Proceedings of the National Academy of Science, Vol. 106, No. 38, September 2009, pp. 16399-16404

17.) M. Wanunu, J. Sutin, and A. Meller, "DNA Profiling Using Solid-State Nanopores: Detection of DNA-Binding Molecules," Nano Letters, 8 July 2009

16.) M. Wanunu, J. Sutin, B. McNally, A. Chow, and A. Meller, "DNA translocation governed by interactions with solid-state nanopores," Biophysical Journal, Vol. 95, November 2008, pp. 1-10

15.) D. Branton, D. W. Deamer, A. Marziali, H. Bayley, S. A. Benner, T. Butler, M. Di Ventra, S. Garaj, A. Hibbs, X. Huang, S. B. Jovanovich, P. S. Krstic, S. Lindsay, X. S. Ling, C. H. Mastrangelo, A. Meller, J. S. Oliver, Y. V. Pershin, J. M. Ramsey, R. Riehn, G. V. Soni, V. Tabard-Cossa, M. Wanunu, M. Wiggin, and J. A. Schloss, "The potential and challenges of nanopore sequencing," Nature Biotechnology, Vol. 26, No. 10, October 2008, pp. 1146-1153

14.) M. Wanunu, B. Chakrabarti, J. Mathé, D. R. Nelson, and A. Meller, "Orientation-dependent interactions of DNA with alpha-hemolysin channel," Physical Review E, Vol. 77, 2008, pp. 031904

13.) B. McNally, M. Wanunu, and A. Meller, "Electromechanical unzipping of individual DNA molecules using synthetic sub-2 nm pores," Nano Letters, Vol. 8, No. 10, 2008, pp. 3418-3422

12.) O. K. Dudko, J. Mathé, A. A. Szabo, A. Meller, and G. Hummer, "Extracting kinetics from single-molecule force spectroscopy: nanopore unzipping of DNA hairpins," Biophysical Journal, Vol. 92, No. 12, 2008, pp. 4188-4195

11.) M. Wanunu, and A. Meller, "Chemically modified solid-state nanopores," Nano Letters, Vol. 7, No. 6, June 2007, pp. 1580-1585

10.) O. K. Dudko, J. Mathé, A. A. Szabo, A. Meller, and G. Hummer, "Extracting kinetics from single-molecule force spectroscopy: Nanopore unzipping of DNA hairpins," Biophysical Journal, Vol. 92, June 2007, pp. 4188-4195

9.) M. Kim, B. McNally, K. Murata, and A. Meller, "Characteristics of solid-state nanometre pores fabricated using a transmission electron microscope," Nanotechnology, Vol. 18, No. 20, 23 May 2007, pp. 205302

8.) B. Hornblower, A. Coombs, R. D. Whitaker, A. Kolomeisky, S. J. Picone, A. Meller, and M. Akeson, "Single-molecule analysis of DNA-protein complexes using nanopores," Nature Methods, Vol. 4, No. 4, April 2007, pp. 315-317

7.) J. B. Edel, J. S. Eid, and A. Meller, "Accurate single molecule FRET efficiency determination for surface immobilized DNA using maximum likelihood calculated lifetimes," Journal of Physical Chemistry B, Vol. 111, No. 11, 22 March 2007, pp. 2986-2990

6.) J. Mathé, A. Arinstein, Y. Rabin, and A. Meller, "Equilibrium and irreversible unzipping of DNA in a nanopore," Europhysics Letters, Vol. 73, 1 January 2006, pp. 128-134

5.) V. Viasnoff, A. Meller, and H. Isambert, "DNA Nanomechanical Switches under Folding Kinetics Control," Nano Letters, Vol. 6, No. 1, 2006, pp. 101-104

4.) J. Mathé, A. Aksimentiev, D. R. Nelson, K. Schulten, and A. Meller, "Orientation discrimination of single-stranded DNA inside the alpha-hemolysin membrane channel," Proceedings of the National Academy of Science, Vol. 102, No. 35, 30 August 2005, pp. 12377–12382

3.) A. Meller, L. Nivon, and D. Branton, "Voltage-Driven DNA Translocations through a Nanopore," Physical Review Letters, Vol. 86, No. 15, 9 April 2001, pp. 3435-3438

2.) A. Meller, L. Nivon, E. Brandin, J. Golovchenko, and D. Branton, "Rapid Nanopore Discrimination between Single Polynucleotide Molecules," Proceedings of the National Academy of Science, Vol. 97, No. 3, 1 February 2000, pp. 1079-1084

1.) T. Tlusty, A. Meller, and R. Bar-Ziv, "Optical Gradient Forces of Strongly Localized Fields," Physical Review Letters, Vol. 81, No. 8, 24 August 1998, pp. 1738-1741

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